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Deep learning-aided inter-species-comparison reveals shared and distinct molecular patterns in cynomolgus monkey and humans following non-specific T cell activation

The early phase of drug development relies on the examination of the efficacy and safety of therapeutic agents in animal models. Due to their close genetic and physiological relation to humans, cynomolgus monkeys (Macaca fascicularis) are a promising animal model in preclinical studies investigating...

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Main Authors: Vincent D. Friedrich, Kari Neier, Kristina Müller, Birgit Fogal, Zuzana Loncova, Michael Rade, Muhammad Shoaib, Ulrike Köhl, Kathleen Hoyt, Parimal Pande, Lily Blanchard, Ernest Raymond, Markus Scholz, Kristin Reiche, Holger Kirsten
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2025-12-01
Series:Frontiers in Immunology
Subjects:
ScRNA-seq
deep learning
cross-species analysis
translational gap
cynomolgus monkey
human
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1603716/full
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