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The fatal trajectory of pulmonary COVID-19 is driven by lobular ischemia and fibrotic remodelling

Summary: Background: COVID-19 is characterized by a heterogeneous clinical presentation, ranging from mild symptoms to severe courses of disease. 9–20% of hospitalized patients with severe lung disease die from COVID-19 and a substantial number of survivors develop long-COVID. Our objective was to...

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Päätekijät: Maximilian Ackermann, Jan C. Kamp, Christopher Werlein, Claire L. Walsh, Helge Stark, Verena Prade, Rambabu Surabattula, Willi L. Wagner, Catherine Disney, Andrew J. Bodey, Thomas Illig, Diana J. Leeming, Morten A. Karsdal, Alexandar Tzankov, Peter Boor, Mark P. Kühnel, Florian P. Länger, Stijn E. Verleden, Hans M. Kvasnicka, Hans H. Kreipe, Axel Haverich, Stephen M. Black, Axel Walch, Paul Tafforeau, Peter D. Lee, Marius M. Hoeper, Tobias Welte, Benjamin Seeliger, Sascha David, Detlef Schuppan, Steven J. Mentzer, Danny D. Jonigk
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Elsevier 2022-11-01
Sarja:EBioMedicine
Aiheet:
COVID-19
Intussusceptive angiogenesis
Fibrogenesis
Biomarkers
Linkit:http://www.sciencedirect.com/science/article/pii/S2352396422004789
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