Computer-aided design of PVR mutants with enhanced binding affinity to TIGIT

Abstract Background TIGIT, as a novel immune checkpoint molecule involved in T cell and NK cell anergy, could induce the immune tolerance and escape through binding with its ligand PVR. Blockade of TIGIT/PVR is considered as a promising strategy in cancer immunotherapy. However, to facilitate the de...

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Detalles Bibliográficos

Principais autores:	Xiaowen Zhou, Jiangfeng Du, Xiuman Zhou, Xiaoshuang Niu, Wanqiong Li, Chunxia Chen, Sifan Lv, Aijun Wu, Shanshan Gou, Yixuan Sun, Wenjie Zhai, Lu Qiu, Yuanming Qi, Wenshan Zhao, Yanfeng Gao
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2021-02-01
Series:	Cell Communication and Signaling
Assuntos:	Cancer immunotherapy TIGIT/PVR Molecular dynamics Mutagenesis Drug design
Acceso en liña:	https://doi.org/10.1186/s12964-020-00701-y
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