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Cellugyrin (synaptogyrin-2) dependent pathways are used by bacterial cytolethal distending toxin and SARS-CoV-2 virus to gain cell entry

Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) is capable of intoxicating lymphocytes macrophages, mast cells and epithelial cells. Following Cdt binding to cholesterol, in the region of membrane lipid rafts, the CdtB and CdtC subunits are internalized and traffic to intrace...

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Principais autores: Kathleen Boesze-Battaglia, Gary H. Cohen, Paul F. Bates, Lisa M. Walker, Ali Zekavat, Bruce J. Shenker
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2024-04-01
Serier:Frontiers in Cellular and Infection Microbiology
Fag:
cellugyrin
synaptogyrin-2
cytolethal distending toxin
SARS-CoV-2
pathogen
cell entry
Online adgang:https://www.frontiersin.org/articles/10.3389/fcimb.2024.1334224/full
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