LDRT combined with anti-PD-1 promotes tumor regression in head and neck squamous cell carcinoma through tumor metaprogram evolution and immune cell reprogramming

Abstract Background Anti–PD-1 (αPD-1) therapy shows limited efficacy in head and neck squamous cell carcinoma (HNSCC), partly due to an immunosuppressive tumor microenvironment (TME) and insufficient infiltration of effector T cells. Low-dose radiotherapy (LDRT) has been suggested to modify the TME,...

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Váldodahkkit:	Guanjun Li, Xiangdi Yang, Linxuan Huang, Yannan Zheng, Liangfu Xu, Zhaoyuan Zhang, Junyan Li, Tingting Li, Yutong Zhang, Yongqin Yang, Yifei Li, Zhigang Liu
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	BMC 2026-02-01
Ráidu:	Journal of Experimental & Clinical Cancer Research
Fáttát:	Neoadjuvant therapy Low-Dose radiotherapy Immunotherapy Head and neck squamous cell carcinoma
Liŋkkat:	https://doi.org/10.1186/s13046-026-03660-3
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