Echinocandin tolerance and persistence in vitro are regulated by calcineurin signaling in Candida glabrata

ABSTRACT Upon exposure to echinocandins, growing yeast cells begin to accumulate cell wall damage and eventually die, resulting in therapeutic effects. While resistance to echinocandins is well studied, tolerance and persistence mechanisms that may also contribute to clinical failures and relapses r...

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Hauptverfasser:	Abigail A. Harrington, Timothy J. Nickels, Kyle W. Cunningham
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology 2026-01-01
Schriftenreihe:	mBio
Schlagworte:	antifungal resistance Candida glabrata Candida albicans tolerance persistence
Online-Zugang:	https://journals.asm.org/doi/10.1128/mbio.02546-25
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