Limited effects of dysfunctional macroautophagy on the accumulation of extracellularly derived α-synuclein in oligodendroglia: implications for MSA pathogenesis

Abstract Background The progressive neurodegenerative disorder multiple system atrophy (MSA) is characterized by α-synuclein-positive (oligodendro-) glial cytoplasmic inclusions (GCIs). A connection between the abnormal accumulation of α-synuclein in GCIs and disease initiation and progression has b...

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Hlavní autoři:	Lisa Fellner, Edith Buchinger, Dominik Brueck, Regina Irschick, Gregor K. Wenning, Nadia Stefanova
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2018-05-01
Edice:	BMC Neuroscience
Témata:	Macroautophagy Multiple system atrophy α-Synuclein Oligodendroglia Glial cytoplasmic inclusions
On-line přístup:	http://link.springer.com/article/10.1186/s12868-018-0431-2
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