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Genetic Characterization and Passage Instability of a Hybrid Plasmid Co-Harboring blaIMP-4 and blaNDM-1 Reveal the Contribution of Insertion Sequences During Plasmid Formation and Evolution

ABSTRACT Carbapenemase is the predominant enzyme in the mechanism leading to Enterobacterales resistance to carbapenems, but only a limited number of isolates harbor double classes/types of carbapenemase. Here, an IMP-4 and NDM-1 producer named Klebsiella michiganensis 7525 is reported, and the co-h...

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Principais autores: Xi Li, Jintao He, Yan Jiang, Minfei Peng, Yunsong Yu, Ying Fu
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2021-12-01
Serija:Microbiology Spectrum
Teme:
Online dostop:https://journals.asm.org/doi/10.1128/Spectrum.01577-21
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