Understanding the Interaction Determinants of CAPN1 Inhibition by CAST4 from Bovines Using Molecular Modeling Techniques

HCV-induced CAPN activation and its effects on virus-infected cells in a host-immune system have been studied recently. It has been shown that the HCV-nonstructural 5A protein acts as both an inducer and a substrate for host CAPN protease; it participates in suppressing the TNF-α-induced apoptosis...

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Autores principales:	Han-Ha Chai, Dajeong Lim, Eunkyoung Jung, Bong-Hwan Choi, Yong-Min Cho
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	MDPI AG 2014-09-01
Colección:	Molecules
Materias:	CAPN1 (μ-calpain) CAST4 (the fourth repetitive calpain-inhibition domain of calpastatin) Bovine CAPN1/CAST4 system computer-aided molecular design anti-BVDV drug
Acceso en línea:	http://www.mdpi.com/1420-3049/19/9/14316
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