Methylation of a CGATA element inhibits binding and regulation by GATA-1

While DNA methylation is thought to play a regulatory role, there are few examples where modification of a single CpG dinucleotide directly affects transcription factor binding. Here the authors show that methylation of a single CGATA element within the c-Kit gene inhibits binding and regulation by...

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Hlavní autoři:	Lu Yang, Zhiliang Chen, Elizabeth S. Stout, Fabien Delerue, Lars M. Ittner, Marc R. Wilkins, Kate G. R. Quinlan, Merlin Crossley
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2020-05-01
Edice:	Nature Communications
On-line přístup:	https://doi.org/10.1038/s41467-020-16388-1
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