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Hapln1 promotes dedifferentiation and proliferation of iPSC-derived cardiomyocytes by promoting versican-based GDF11 trapping

Hyaluronan and proteoglycan link protein 1 (Hapln1) supports active cardiomyogenesis in zebrafish hearts, but its regulation in mammal cardiomyocytes is unclear. This study aimed to explore the potential regulation of Hapln1 in the dedifferentiation and proliferation of cardiomyocytes and its therap...

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Principais autores: Ding-Jun Hao, Yue Qin, Shi-Jie Zhou, Bu-Huai Dong, Jun-Song Yang, Peng Zou, Li-Ping Wang, Yuan-Ting Zhao
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2024-03-01
Serier:Journal of Pharmaceutical Analysis
Fag:
Hapln1
Versican
GDF11
iPSC-CMs
Cardiomyocyte proliferation
Online adgang:http://www.sciencedirect.com/science/article/pii/S2095177923002514
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