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Melatonin Acts as an Antidepressant by Inhibition of the Acid Sphingomyelinase/Ceramide System

Background: Melatonin has been shown to have antidepressive effects. We tested whether melatonin inhibits the acid sphingomyelinase/ceramide system and mediates its antidepressive effects via inhibition of the acid sphingomyelinase and a reduction of ceramide in the hippocampus. Antidepressants such...

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Furkejuvvon:
Váldodahkkit: Richard Hoehn, Marlene Monse, Ella Pohl, Sina Wranik, Barbara Wilker, Simone Keitsch, Matthias Soddemann, Johannes Kornhuber, Marcus Kohnen, Michael J. Edwards, Heike Grassmé, Erich Gulbins
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Cell Physiol Biochem Press GmbH & Co KG 2016-07-01
Ráidu:Neurosignals
Fáttát:
Melatonin
Major depression
Acid sphingomyelinase
Ceramide
Neurogenesis
Liŋkkat:http://www.karger.com/Article/FullText/442611
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