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Mice lacking DKK1 in T cells exhibit high bone mass and are protected from estrogen-deficiency-induced bone loss

Summary: The Wnt inhibitor Dickkopf-1 (DKK1) is a negative regulator of bone formation and bone mass and is dysregulated in various bone diseases. How DKK1 contributes to postmenopausal osteoporosis, however, remains poorly understood. Here, we show that mice lacking DKK1 in T cells are protected fr...

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Xehetasun bibliografikoak
Egile Nagusiak: Juliane Lehmann, Sylvia Thiele, Ulrike Baschant, Tilman D. Rachner, Christof Niehrs, Lorenz C. Hofbauer, Martina Rauner
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Elsevier 2021-03-01
Saila:iScience
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Sarrera elektronikoa:http://www.sciencedirect.com/science/article/pii/S2589004221001929
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