Wharton's Jelly mesenchymal stromal cell‐derived extracellular vesicles promote nucleus pulposus cell anabolism in an in vitro 3D alginate‐bead culture model

Abstract Background Intradiscal transplantation of mesenchymal stromal cells (MSCs) has emerged as a promising therapy for intervertebral disc degeneration (IDD). However, the hostile microenvironment of the intervertebral disc (IVD) may compromise the survival of implanted cells. Interestingly, stu...

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Bibliografische Detailangaben

Hauptverfasser:	Veronica Tilotta, Gianluca Vadalà, Luca Ambrosio, Giuseppina Di Giacomo, Claudia Cicione, Fabrizio Russo, Adas Darinskas, Rocco Papalia, Vincenzo Denaro
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Wiley 2024-03-01
Schriftenreihe:	JOR Spine
Schlagworte:	exosome extracellular vesicles intervertebral disc intervertebral disc degeneration intervertebral disc regeneration low back pain
Online-Zugang:	https://doi.org/10.1002/jsp2.1274
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