Enhancement of systemic and lung-localized CD4⁺ T-cell immune responses by truncation of NS1 protein of a seasonal live influenza vaccine strain

Introduction. There is a large variety of licensed influenza vaccines worldwide, but their common limitation is rather narrow specificity and inability to protect against antigenic-drift variants of influenza virus. Therefore, optimization of immunogenic and cross-protective properties of licensed i...

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Principais autores:	Polina I. Prokopenko, Ekaterina A. Stepanova, Victoria A. Matyushenko, Alexandra Ya. Rak, Anna K. Chistyakova, Arina D. Kostromitina, Tatyana S. Kotomina, Igor V. Kudryavtsev, Artem A. Rubinstein, Alexey S. Komlev, Larisa G. Rudenko, Irina N. Isakova-Sivak
Formato:	Artigo
Idioma:	Russo
Publicado:	Central Research Institute for Epidemiology 2024-11-01
Series:	Журнал микробиологии, эпидемиологии и иммунобиологии
Assuntos:	influenza virus live attenuated influenza vaccine ns1 protein memory t cells tissue-resident memory t cells cd4+ т cells, cd8+ т cells
Acceso en liña:	https://microbiol.crie.ru/jour/article/viewFile/18682/1518
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