KinOrtho: a method for mapping human kinase orthologs across the tree of life and illuminating understudied kinases

Abstract Background Protein kinases are among the largest druggable family of signaling proteins, involved in various human diseases, including cancers and neurodegenerative disorders. Despite their clinical relevance, nearly 30% of the 545 human protein kinases remain highly understudied. Comparati...

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Principais autores:	Liang-Chin Huang, Rahil Taujale, Nathan Gravel, Aarya Venkat, Wayland Yeung, Dominic P. Byrne, Patrick A. Eyers, Natarajan Kannan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2021-09-01
coleção:	BMC Bioinformatics
Assuntos:	Protein kinase Bioinformatics Orthology Understudied proteins Annotation inference
Acesso em linha:	https://doi.org/10.1186/s12859-021-04358-3
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