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Metabolic modeling of single bronchoalveolar macrophages reveals regulators of hyperinflammation in COVID-19

Summary: SARS-CoV-2 infection induces imbalanced immune response such as hyperinflammation in patients with severe COVID-19. Here, we studied the immunometabolic regulatory mechanisms for the pathogenesis of COVID-19. We depicted the metabolic landscape of immune cells, especially macrophages, from...

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Principais autores: Qiuchen Zhao, Zhenyang Yu, Shengyuan Zhang, Xu-Rui Shen, Hao Yang, Yangyang Xu, Yang Liu, Lin Yang, Qing Zhang, Jiaqi Chen, Mengmeng Lu, Fei Luo, Mingming Hu, Yan Gong, Conghua Xie, Peng Zhou, Li Wang, Lishan Su, Zheng Zhang, Liang Cheng
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2022-11-01
Serier:iScience
Fag:
Biological sciences
Immunology
Virology
Bioinformatics
Online adgang:http://www.sciencedirect.com/science/article/pii/S2589004222015917
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