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Development and Application of Automated Sandwich ELISA for Quantitating Residual dsRNA in mRNA Vaccines

The rise of mRNA as a novel vaccination strategy presents new opportunities to confront global disease. Double-stranded RNA (dsRNA) is an impurity byproduct of the in vitro transcription reaction used to manufacture mRNA that may affect the potency and safety of the mRNA vaccine in patients. Careful...

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Збережено в:
Автори: David A. Holland, Jillian Acevedo-Skrip, Joshua Barton, Rachel Thompson, Amy Bowman, Emily A. Dewar, Danielle V. Miller, Kaixi Zhao, Andrew R. Swartz, John W. Loughney
Формат: Artigo
Мова:Inglês
Опубліковано: MDPI AG 2024-08-01
Серія:Vaccines
Предмети:
mRNA
dsRNA
sandwich ELISA
high throughput
automation
Онлайн доступ:https://www.mdpi.com/2076-393X/12/8/899
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