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Renoprotection of Microcystin-RR in Unilateral Ureteral Obstruction-Induced Renal Fibrosis: Targeting the PKM2-HIF-1α Pathway

Renal fibrosis is a pathological characteristic of the endpoint of chronic kidney disease (CKD), which remains a major public health problem. None of the current therapies is effective in stopping kidney fibrosis progression. In light of our novel detection of a potential antifibrosis of microcystin...

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Autori principali: Yan Ren, Jie Wang, Wenwen Guo, Jingwen Chen, Xin Wu, Shubo Gu, Lizhi Xu, Zhiwei Wu, Yaping Wang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2022-06-01
Serie:Frontiers in Pharmacology
Soggetti:
microcystin-RR (MC-RR)
renoprotection
renal fibrosis
PKM2
HIF-1α
Accesso online:https://www.frontiersin.org/articles/10.3389/fphar.2022.830312/full
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