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KRAS: Biology, Inhibition, and Mechanisms of Inhibitor Resistance

KRAS is a small GTPase that is among the most commonly mutated oncogenes in cancer. Here, we discuss KRAS biology, therapeutic avenues to target it, and mechanisms of resistance that tumors employ in response to KRAS inhibition. Several strategies are under investigation for inhibiting oncogenic KRA...

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Main Authors: Leonard J. Ash, Ottavia Busia-Bourdain, Daniel Okpattah, Avrosina Kamel, Ariel Liberchuk, Andrew L. Wolfe
Format: Artigo
Language:Inglês
Published: MDPI AG 2024-04-01
Series:Current Oncology
Subjects:
KRAS
cancer
immunotherapy
targeted therapy
resistance
oncogene
Online Access:https://www.mdpi.com/1718-7729/31/4/150
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