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Abnormal Accumulation of Collagen Type I Due to the Loss of Discoidin Domain Receptor 2 (Ddr2) Promotes Testicular Interstitial Dysfunction.

Loss of functional allele for discoidin domain receptor 2 (Ddr2) results in impaired Leydig cell response to luteinizing hormone (LH), low testosterone production and arrested spermatogenesis in older male Ddr2slie/slie mice. However, the underlying mechanism responsible for this phenotype remains u...

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Principais autores: Chu-chao Zhu, Bin Tang, Jin Su, Hu Zhao, Xin Bu, Zhen Li, Jie Zhao, Wei-dong Gong, Zhi-qun Wu, Li-bo Yao, Wei Li, Yuan-qiang Zhang
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2015-01-01
Serier:PLoS ONE
Online adgang:http://europepmc.org/articles/PMC4497730?pdf=render
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