Oligomerization-dependent and synergistic regulation of Cdc42 GTPase cycling by a GEF and a GAP

Abstract Cell polarity is a crucial biological process essential for cell division, directed growth, and motility. In Saccharomyces cerevisiae, polarity establishment centers around the small Rho-type GTPase Cdc42, which cycles between GTP-bound and GDP-bound states, regulated by GEFs like Cdc24 and...

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Detalhes bibliográficos

Principais autores:	Sophie Tschirpke, Werner K-G Daalman, Frank van Opstal, Liedewij Laan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Springer Nature 2026-02-01
coleção:	EMBO Reports
Assuntos:	GTPase Activity Cdc42 Regulation GEF-GAP Synergy Enzyme Kinetics Oligomerization
Acesso em linha:	https://doi.org/10.1038/s44319-026-00695-7
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