Influence of the broadly neutralizing antibody VRC01 on HIV breakthrough virus populations in antibody-mediated prevention trials

Abstract In the antibody mediated prevention (AMP) trials, the broadly neutralizing antibody (bNAb) VRC01 demonstrated protective efficacy against susceptible HIV strains. To understand how VRC01 shaped breakthrough infections, deep sequencing was performed on 172 participants (>100,000 gag-Δpol and...

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Principais autores:	Carolyn Williamson, Chivonne Moodley, Craig A. Magaret, Elena E. Giorgi, Morgane Rolland, Dylan H. Westfall, Anna Yssel, Wenjie Deng, Raabya Rossenkhan, Nonhlanhla N. Mkhize, Lennie Chen, Hong Zhao, Tanmoy Bhattacharya, Alec Pankow, Ben Murrell, Talita York, Asanda Gwashu-Nyangiwe, Nonkululeko Ndabambi, Ruwayhida Thebus, Paula Cohen, Bronwen Lambson, Haajira Kaldine, Sinethemba Bhebhe, Michal Juraska, Hongjun Bai, Allan C. deCamp, Maurine D. Miner, James Ludwig, Cindy Molitor, Nicolas Beaume, David Matten, Yunda Huang, Lily Zhang, Daniel B. Reeves, Bryan Mayer, Shelly T. Karuna, John A. Hural, Lynn Morris, David Montefiori, Roger E. Bumgarner, Penny L. Moore, Paul T. Edlefsen, Srilatha Edupuganti, Nyaradzo Mgodi, M. Juliana McElrath, Myron S. Cohen, Lawrence Corey, Peter B. Gilbert, James I. Mullins
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2026-04-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-026-70888-0
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