WHOPPA Enables Parallel Assessment of Leucine-Rich Repeat Kinase 2 and Glucocerebrosidase Enzymatic Activity in Parkinson’s Disease Monocytes

Both leucine-rich repeat kinase 2 (LRRK2) and glucocerebrosidase (GCase) are promising targets for the treatment of Parkinson’s disease (PD). Evidence suggests that both proteins are involved in biological pathways involving the lysosome. However, studies to date have largely investigated the enzyme...

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Detalhes bibliográficos

Principais autores:	Rebecca L. Wallings, Laura P. Hughes, Hannah A. Staley, Zachary D. Simon, Nikolaus R. McFarland, Roy N. Alcalay, Alicia Garrido, María José Martí, Eduardo Tolosa Sarró, Nicolas Dzamko, Malú Gámez Tansey
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-06-01
coleção:	Frontiers in Cellular Neuroscience
Assuntos:	LRRK2 GCase Parkinson’s biomarker monocytes lysosome
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fncel.2022.892899/full
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