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Antiviral HIV-1 SERINC restriction factors disrupt virus membrane asymmetry

Abstract The host proteins SERINC3 and SERINC5 are HIV-1 restriction factors that reduce infectivity when incorporated into the viral envelope. The HIV-1 accessory protein Nef abrogates incorporation of SERINCs via binding to intracellular loop 4 (ICL4). Here, we determine cryoEM maps of full-length...

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Príomhchruthaitheoirí: Susan A. Leonhardt, Michael D. Purdy, Jonathan R. Grover, Ziwei Yang, Sandra Poulos, William E. McIntire, Elizabeth A. Tatham, Satchal K. Erramilli, Kamil Nosol, Kin Kui Lai, Shilei Ding, Maolin Lu, Pradeep D. Uchil, Andrés Finzi, Alan Rein, Anthony A. Kossiakoff, Walther Mothes, Mark Yeager
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Nature Portfolio 2023-07-01
Sraith:Nature Communications
Rochtain ar líne:https://doi.org/10.1038/s41467-023-39262-2
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