Proton pump inhibitor co-therapy in patients receiving non-vitamin K antagonist oral anticoagulants: current evidence, gastrointestinal bleeding prevention, and clinical considerations

BackgroundNon-vitamin K antagonist oral anticoagulants (NOACs) are widely prescribed for stroke prevention in atrial fibrillation (AF). Although they reduce intracranial hemorrhage compared with warfarin, gastrointestinal bleeding (GIB), particularly upper GIB (UGIB), remains a clinically significan...

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Bibliografische gegevens

Hoofdauteurs:	Dong-Hyeok Kim, Yeji Kim, Moon-Hyun Kim, Jeongmin Kang, Junbeom Park
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Frontiers Media S.A. 2026-06-01
Reeks:	Frontiers in Cardiovascular Medicine
Onderwerpen:	atrial fibrillation (AF) gastroprotection non-vitamin K antagonist oral anticoagulants (NOAC) pharmacoepidemiology proton pump inhibitors (PPI) upper gastrointestinal bleeding (UGIB)
Online toegang:	https://www.frontiersin.org/articles/10.3389/fcvm.2026.1816099/full
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