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Tissue-specific responses of IGF-1/insulin and mTOR signaling in calorie restricted rats.

Moderate calorie restriction (CR) (∼60% of ad libitum, AL, intake) has been associated with numerous favorable physiological outcomes in many species, and the insulin/IGF-1 and mTOR signaling pathways have each been proposed as potential mediators for many of CR's bioeffects. However, few studies ha...

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Principais autores: Naveen Sharma, Carlos M Castorena, Gregory D Cartee
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Acceso en liña:http://europepmc.org/articles/PMC3368930?pdf=render
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