No detectable differences in Nef-mediated downregulation of HLA-I and CD4 molecules among HIV-1 group M lineages circulating in Cameroon, where the pandemic originated

HIV-1 group M (HIV-1M) lineages downregulate HLA-I and CD4 expression via their Nef proteins. We hypothesized that these Nef functions may be partially responsible for the differences in prevalence of viruses from different lineages that co-circulate within an epidemic. Here, we characterized these...

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Autori principali:	Nelson Sonela, Jaclyn Mann, Celestin Godwe, Oumarou H. Goni, Mérime Tchakoute, Nathalie Nkoue, Tulio de Oliveira, Mark A. Brockman, Zabrina L. Brumme, Thumbi Ndung’u, Marcel Tongo
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2024-05-01
Serie:	Frontiers in Virology
Soggetti:	HIV-1 group M HIV-1 Nef HLA-I downregulation CD4 downregulation Cameroon
Accesso online:	https://www.frontiersin.org/articles/10.3389/fviro.2024.1379217/full
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