Pulmonary SARS-CoV-2 infection leads to para-infectious immune activation in the brain

Neurological complications, including encephalopathy and stroke, occur in a significant proportion of COVID-19 cases but viral protein is seldom detected in the brain parenchyma. To model this situation, we developed a novel low-inoculum K18-hACE2 mouse model of SARS-CoV-2 infection during which act...

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Principais autores:	Cordelia Dunai, Claire Hetherington, Sarah A. Boardman, Jordan J. Clark, Parul Sharma, Krishanthi Subramaniam, Kukatharmini Tharmaratnam, Edward J. Needham, Robyn Williams, Yun Huang, Greta K. Wood, Ceryce Collie, Andrew Fower, Hannah Fox, Mark A. Ellul, Marie Held, Franklyn N. Egbe, Michael Griffiths, Tom Solomon, Gerome Breen, Anja Kipar, Jonathan Cavanagh, Sarosh R. Irani, Angela Vincent, James P. Stewart, Leonie S. Taams, David K. Menon, Benedict D. Michael
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2024-10-01
coleção:	Frontiers in Immunology
Assuntos:	virology immunology SARS-CoV-2 neurology microglia
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1440324/full
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