Vaccination of newborn monkeys with an influenza HA stem nanoparticle adjuvanted with R848 and AddaVax results in broadened HA recognition and increased antibody secreting cells to HA stem following H1N1 challenge

BackgroundHow infection shapes recall responses in the setting of preexisting influenza virus hemagglutinin (HA) stem-focused immunity has important implications given the known impact of imprinting on future immune responses. Adoption of an HA-based universal stem vaccine approach for young infants...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Kali F. Crofts, Beth C. Holbrook, Colby J. Hendrix, Ava C. DiPaolo, Courtney L. Page, Rebecca A. Gillespie, Heather A. Burkart, Masaru Kanekiyo, Martha A. Alexander-Miller
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2026-08-01
Schriftenreihe:	Frontiers in Immunology
Schlagworte:	adjuvants antibody secreting cell influenza HA stem influenza vaccine memory B cell newborn
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1934178/full
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