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Suppression of Mig-6 overcomes the acquired EGFR-TKI resistance of lung adenocarcinoma

Abstract Background The resistance of lung cancer to epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) is one of the unconquered frontiers in chemotherapy. Mitogen-inducible gene 6 (Mig-6) is known to inhibit the kinase activity of epidermal growth factor receptor (EGFR). Similar...

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Principais autores: Da Hyun Kang, Sung Soo Jung, Min-Kyung Yeo, Da Hye Lee, Geon Yoo, Sang Yeon Cho, In-Jae Oh, Ju-Ock Kim, Hee Sun Park, Chaeuk Chung, Jeong Eun Lee
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2020-06-01
Serier:BMC Cancer
Fag:
Mig-6
EGFR-TKI
Lung adenocarcinoma
Chemotherapy resistance
Online adgang:http://link.springer.com/article/10.1186/s12885-020-07057-z
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