Parkinson’s disease-associated PLA2G6 protects IP3R1 protein to control ER-mitochondria tethering and Ca2+ transfer

Abstract Mutations in the phospholipase A2 group VI (PLA2G6) gene have been linked to autosomal recessive Parkinson’s disease (PD), yet the molecular mechanisms remain poorly understood. This study provides the in vitro and in vivo evidence, specifically in dopaminergic neurons derived from patients...

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Autori principali:	Zhi-Hao Lin, Nai-Jia Xue, Yi Liu, Feng Zhang, Xiao-Li Si, Ran Zheng, Lu-Yan Gu, Yao-Lin Li, Yi Fan, Jun Tian, Wolfgang H. Oertel, Hyemyung Seo, Jia-Li Pu, Bao-Rong Zhang
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2026-03-01
Serie:	Nature Communications
Accesso online:	https://doi.org/10.1038/s41467-026-70752-1
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