Highly sensitive visual restoration and protection via ectopic expression of chimeric rhodopsin in mice
Summary: Photoreception requires amplification by mammalian rhodopsin through G protein activation, which requires a visual cycle. To achieve this in retinal gene therapy, we incorporated human rhodopsin cytoplasmic loops into Gloeobacter rhodopsin, thereby generating Gloeobacter and human chimeric...
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| Huvudupphov: | , , , , , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Utgiven: |
Elsevier
2023-10-01
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| Serie: | iScience |
| Ämnen: | |
| Länkar: | http://www.sciencedirect.com/science/article/pii/S2589004223017935 |
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