Gestational hypothyroxinemia causes an inflammatory environment at maternal-fetal tissues and fetal brain with impaired hippocampal dendritic spine maturation in the offspring

Abstract Gestational hypothyroxinemia (HTX) is associated with cognitive impairments and autism traits in offspring. However, the underlying mechanisms remain unclear. Prenatal inflammation impairs cortical development and induces diverse neurodevelopmental outcomes. Since thyroid dysfunction elicit...

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Autores principales:	Enrique González-Madrid, Ma. Andreina Rangel-Ramírez, María C. Opazo, Sebastián A. Espinoza, Daniela Elgueta, Gonzalo I. Cancino, Elena Mery, Álvaro O. Ardiles, Luisa F. Duarte, Jorge A. Soto, Leandro J. Carreño, Felipe Simon, Susan M. Bueno, Pablo A. González, Alexis M. Kalergis, Claudia A. Riedel
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Portfolio 2025-11-01
Colección:	Scientific Reports
Materias:	Gestational hypothyroxinemia Prenatal inflammation Cytokines Maternal-fetal interface Embryonic neurodevelopment Microglia
Acceso en línea:	https://doi.org/10.1038/s41598-025-26206-7
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