GAPDH inhibition mediated by thiol oxidation in human airway epithelial cells exposed to an environmental peroxide

Intracellular redox homeostasis in the airway epithelium is closely regulated through adaptive signaling and metabolic pathways. However, inhalational exposure to xenobiotic stressors such as secondary organic aerosols (SOA) can alter intracellular redox homeostasis. Isoprene hydroxy hydroperoxide (...

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Principais autores:	Syed Masood, Hye-Young H. Kim, Edward R. Pennington, Keri A. Tallman, Ned A. Porter, Philip A. Bromberg, Rebecca L. Rice, Avram Gold, Zhenfa Zhang, James M. Samet
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2024-07-01
coleção:	Redox Biology
Assuntos:	Air pollution Cellular bioenergetics GAPDH (glyceraldehyde-3-phosphate dehydrogenase) Oxidative stress Protein thiol oxidation Secondary organic aerosols
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2213231724001770
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