A novel, somatic, transforming mutation in the extracellular domain of Epidermal Growth Factor Receptor identified in myeloproliferative neoplasm

Abstract We describe a novel ERBB1/EGFR somatic mutation (p. C329R; c.985 T > C) identified in a patient with JAK2V617F Polycythaemia Vera (PV). This substitution affects a conserved cysteine residue in EGFR domain 2 and leads to the formation of a ligand-independent covalent receptor dimer, associa...

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Principais autores:	D. A. Casolari, T. Nguyen, C. M. Butcher, D. G. Iarossi, C. N. Hahn, S. C. Bray, P. Neufing, W. T. Parker, J. Feng, K. Z. Y. Maung, A. Wee, L. Vidovic, C. H. Kok, P. G. Bardy, S. Branford, I. D. Lewis, S. W. Lane, H. S. Scott, D. M. Ross, R. J. D’Andrea
Format:	Artigo
Jezik:	Inglês
Izdano:	Nature Portfolio 2017-05-01
Serija:	Scientific Reports
Online dostop:	https://doi.org/10.1038/s41598-017-02655-7
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