Design, synthesis, molecular docking and cytotoxic evaluation of novel pyrimidine-based sulfonamide derivatives as potent anticancer agents: SAR insights and biological profiling

Abstract The low selectivity and significant toxicity of current chemotherapeutic medicines make the research and development of novel anticancer agents an urgent necessity. This study used IR, NMR, MS, and elemental studies to rationally design, synthesize, and structurally characterize a novel cla...

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Hauptverfasser:	Nesma M. Bayoumy, Ahmed A. Fadda, Hatem E. Gaffer, Nanees N. Soliman
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2026-03-01
Schriftenreihe:	Scientific Reports
Schlagworte:	Sulfonamide Pyrazole Thiazole Pyrimidine Anticancer Agents Molecular Docking
Online-Zugang:	https://doi.org/10.1038/s41598-026-41711-z
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