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Activation of TMEM16A Ca2+-activated Cl− channels by ROCK1/moesin promotes breast cancer metastasis

Introduction: Transmembrane protein 16A (TMEM16A) is a Ca2+-activated chloride channel that plays a role in cancer cell proliferation, migration, invasion, and metastasis. However, whether TMEM16A contributes to breast cancer metastasis remains unknown. Objective: In this study, we investigated whet...

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Principais autores: Shuya Luo, Hui Wang, Lichuan Bai, Yiwen Chen, Si Chen, Kuan Gao, Huijie Wang, Shuwei Wu, Hanbin Song, Ke Ma, Mei Liu, Fan Yao, Yue Fang, Qinghuan Xiao
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021-11-01
coleção:Journal of Advanced Research
Assuntos:
TMEM16A
Cl− channel
Metastasis
ROCK1
Moesin
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2090123221000527
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