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Evidence for NADPH oxidase activation by GPR40 in pancreatic β-cells

Objective: Investigate the involvement of the fatty acids receptor GPR40 in the assembly and activation of NADPH oxidase and the implications on pancreatic β-cell function. Methods: BRIN-BD11 β-cells were exposed to GPR40 agonist (GW9508) or linoleic acid in different glucose concentrations. Superox...

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Autori principali: Gabriela Nunes Marsiglio-Librais, Eloisa Aparecida Vilas-Boas, Christopher Carlein, Markus Daniel Alexander Hoffmann, Leticia Prates Roma, Angelo Rafael Carpinelli
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis Group 2020-01-01
Serie:Redox Report
Soggetti:
gpr40
nadph oxidase
ros
p47phox translocation
brin-bd11
gw9508
linoleic acid
nox2 ko islets
rogfp2-orp1
insulin secretion
Accesso online:http://dx.doi.org/10.1080/13510002.2020.1757877
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