PACAP inhibits β-cell mass expansion in a mouse model of type II diabetes: persistent suppressive effects on islet density

Pituitary adenylate cyclase-activating polypeptide (PACAP) is a potent insulinotropic G-protein-coupled receptor ligand, for which morphoregulative roles in pancreatic islets have recently been suggested. Here, we evaluated the effects of pancreatic overexpression of PACAP on morphometric changes of...

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Detaylı Bibliyografya
Asıl Yazarlar:	Hiroaki eInoue, Norihito eShintani, Yusuke eSakurai, Shintaro eHigashi, Atsuko eHayata-Takano, Akemichi eBaba, Hitoshi eHashimoto
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	Frontiers Media S.A. 2013-03-01
Seri Bilgileri:	Frontiers in Endocrinology
Konular:	Pituitary Adenylate Cyclase-Activating Polypeptide type 2 diabetes high-fat diet β cells KKAy mice islet neogenesis
Online Erişim:	http://journal.frontiersin.org/Journal/10.3389/fendo.2013.00027/full
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PACAP inhibits β-cell mass expansion in a mouse model of type II diabetes: persistent suppressive effects on islet density

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