Suppression of the METTL3-m6A-integrin β1 axis by extracellular acidification impairs T cell infiltration and antitumor activity

Summary: The acidic metabolic byproducts within the tumor microenvironment (TME) hinder T cell effector functions. However, their effects on T cell infiltration remain largely unexplored. Leveraging the comprehensive The Cancer Genome Atlas dataset, we pinpoint 16 genes that correlate with extracell...

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Detalhes bibliográficos

Principais autores:	Zhe Wang, Jingzhe Shang, Yajing Qiu, Hongcheng Cheng, Mengyuan Tao, Ermei Xie, Xin Pei, Wenhui Li, Lianjun Zhang, Aiping Wu, Guideng Li
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2024-02-01
coleção:	Cell Reports
Assuntos:	CP: Immunology CP: Cancer
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2211124724001244
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