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C/EBPα regulates the fate of bone marrow mesenchymal stem cells and steroid-induced avascular necrosis of the femoral head by targeting the PPARγ signalling pathway

Abstract Background The imbalance of osteogenic/adipogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) is closely related to steroid-induced avascular necrosis of the femoral head (SANFH). We aimed to investigate the epigenetic mechanism of intramedullary fat accumulation and conti...

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Principais autores: Ping Duan, Hanyu Wang, Xinzeyu Yi, Hao Zhang, Hui Chen, Zhenyu Pan
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2022-07-01
Serier:Stem Cell Research & Therapy
Fag:
SANFH
C/EBPα
PPARγ
Acetylation
Adipogenic differentiation
Online adgang:https://doi.org/10.1186/s13287-022-03027-3
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