Wnt-regulated lncRNA discovery enhanced by in vivo identification and CRISPRi functional validation

Abstract Background Wnt signaling is an evolutionarily conserved developmental pathway that is frequently hyperactivated in cancer. While multiple protein-coding genes regulated by Wnt signaling are known, the functional lncRNAs regulated by Wnt signaling have not been systematically characterized....

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Hlavní autoři:	Shiyang Liu, Nathan Harmston, Trudy Lee Glaser, Yunka Wong, Zheng Zhong, Babita Madan, David M. Virshup, Enrico Petretto
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2020-10-01
Edice:	Genome Medicine
Témata:	Functional lncRNAs Wnt signaling Cancer CRISPRi screen
On-line přístup:	http://link.springer.com/article/10.1186/s13073-020-00788-5
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