Adaptive Metabolic Responses Facilitate Blood‐Brain Barrier Repair in Ischemic Stroke via BHB‐Mediated Epigenetic Modification of ZO‐1 Expression

Abstract Adaptive metabolic responses and innate metabolites hold promising therapeutic potential for stroke, while targeted interventions require a thorough understanding of underlying mechanisms. Adiposity is a noted modifiable metabolic risk factor for stroke, and recent research suggests that it...

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Autori principali:	Ruijie Li, Yilin Liu, Jihao Wu, Xiong Chen, Qiying Lu, Kai Xia, Congyuan Liu, Xin Sui, Yixuan Liu, Yiling Wang, Yuan Qiu, Jinsi Chen, Yi Wang, Ruijun Li, Yucheng Ba, Jiayun Fang, Weijun Huang, Zhengqi Lu, Yanbing Li, Xinxue Liao, Andy Peng Xiang, Yinong Huang
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Wiley 2024-07-01
Serie:	Advanced Science
Soggetti:	adipose blood brain barrier (BBB) ketone body lysine β‐hydroxybutyrylation (Kbhb) ZO‐1
Accesso online:	https://doi.org/10.1002/advs.202400426
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