Effect of Denervation on Skeletal Muscle Mitochondria in Heterozygous mtDNA Mutator Mice

ABSTRACT Mitochondrial function is essential for skeletal muscle health, and its disruption leads to atrophy and functional decline. This study examines the impact of denervation on skeletal muscle mitochondria in polymerase gamma (PolG)(+/mut) mice, which accumulate mitochondrial DNA (mtDNA) mutati...

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Principais autores:	Takanaga Shirai, Hideto Hanakita, Kohei Takeda, Yu Kitaoka, Kaori Ishikawa, Kazuto Nakada, Tohru Takemasa
Format:	Artigo
Jezik:	Inglês
Izdano:	Wiley 2026-02-01
Serija:	FASEB BioAdvances
Teme:	atrophy mitochondria mtDNA oxidative stress polymerase gamma skeletal muscle
Online dostop:	https://doi.org/10.1096/fba.2025-00072
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