Annotation and comparative analysis of T cell receptor germline genes reveal lineage-specific patterns in pinnipeds

Adaptive immunity in jawed vertebrates relies on V(D)J recombination, yet the expansion–contraction dynamics of germline genes remain underexplored, especially in secondary aquatic mammals. We present the first systematic annotation of TRA/TRB germline genes in semi-aquatic carnivores—pinnipeds (Eum...

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Autori principali:	Huan Qin, Long Ma, Jun Li, Fengli Wu, Huifang Wang, Qianqian Li, Xiaoji Pan, Xinsheng Yao
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2026-04-01
Serie:	Frontiers in Immunology
Soggetti:	pinnipeds secondary aquatic adaptation T cell receptor TCR repertoire TR annotation
Accesso online:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1775352/full
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