Carfilzomib shows therapeutic potential for reduction of liver fibrosis by targeting hepatic stellate cell activation

Abstract Because hepatic stellate cells (HSCs) play a major role in fibrosis, we focused on HSCs as a potential target for the treatment of liver fibrosis. In this study, we attempted to identify drug candidates to inactivate HSCs and found that several proteasome inhibitors (PIs) reduced HSC viabil...

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Detalhes bibliográficos

Principais autores:	Ayana Fujiwara, Keisuke Takemura, Anna Tanaka, Misaki Matsumoto, Masato Katsuyama, Takeshi Okanoue, Kanji Yamaguchi, Yoshito Itoh, Kazumi Iwata, Kikuko Amagase, Atsushi Umemura
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2024-08-01
coleção:	Scientific Reports
Assuntos:	Proteasome inhibitor Carfilzomib Hepatic stellate cell Liver fibrosis
Acesso em linha:	https://doi.org/10.1038/s41598-024-70296-8
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