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NAD(P)H: quinone oxidoreductase 1 attenuates oxidative stress and apoptosis by regulating Sirt1 in diabetic nephropathy

Abstract Background Diabetic nephropathy (DN) is one of the main complications of diabetes, and oxidative stress plays an important role in its progression. NAD(P)H: quinone oxidoreductase 1 (NQO1) protects cells from oxidative stress and toxic quinone damage. In the present study, we aimed to inves...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Duojun Qiu, Shan Song, Yuhan Wang, Yawei Bian, Ming Wu, Haijiang Wu, Yonghong Shi, Huijun Duan
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2022-01-01
Schriftenreihe:Journal of Translational Medicine
Schlagworte:
Diabetic nephropathy
NQO1
Sirt1
Oxidative stress
Apoptosis
Online-Zugang:https://doi.org/10.1186/s12967-021-03197-3
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