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Limited Immune-Mediated Efficacy of Anti-PD-L1/VEGF in EGFR-TKI-Naïve <i>Egfr</i>-Mutant Lung Cancer with Non-Inflamed Tumor Microenvironment

Immune checkpoint inhibitors (ICIs) show limited efficacy in epidermal growth factor receptor (<i>EGFR</i>)-mutant lung adenocarcinoma due to its non-inflamed tumor microenvironment (TME). While quadruple therapy combining chemotherapy, anti-programmed death-ligand 1 (PD-L1), and anti-vascular endot...

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Hlavní autoři: Atsuko Hirabae, Tadahiro Kuribayashi, Shuta Tomida, Sachi Okawa, Takamasa Nakasuka, Kazuya Nishii, Jun Nishimura, Go Makimoto, Kiichiro Ninomiya, Hisao Higo, Kammei Rai, Eiki Ichihara, Katsuyuki Hotta, Masamichi Sugimoto, Yosuke Togashi, Yoshinobu Maeda, Katsuyuki Kiura, Kadoaki Ohashi
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI AG 2026-05-01
Edice:Current Oncology
Témata:
EGFR mutation
non-small cell lung cancer
syngeneic mouse model
antitumor immunity
non-inflamed tumor
VEGF
On-line přístup:https://www.mdpi.com/1718-7729/33/6/315
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