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Total synthesis and biological evaluation of Koshidacin B, TAN-1746, and Ac-TAN-1746

Abstract Analogues of chlamydocin derivatives consistently demonstrate multifaceted bioactivities, particularly through HDAC inhibition mechanisms, oncolytic efficacy, and neuronal preservation capacities. These activities primarily originate from their unique cyclic tetrapeptide scaffold and functi...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Xiong-En Long, Hailiang Xing, Yixin He, Xuanli Meng, Yanling Ma, Chang Liu, Xi Cao, Huiru Nan, Min-Jing Cheng, Jia-Lei Yan, Junyang Liu
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2025-07-01
Schriftenreihe:BMC Chemistry
Schlagworte:
Total synthesis
Chlamydocin analog
Koshidacin B
TAN-1746
Cross metathesis
Online-Zugang:https://doi.org/10.1186/s13065-025-01581-4
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